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The Forgotten HisTORy of Surendra Nath Sehgal: Discovery of Rapamycin

From the Soil of Rapa Nui to the Brain’s Control Center: The Evolution of Metabolic Medicine

The narrative of modern metabolic medicine reminds us that transformative breakthroughs often emerge from unexpected origins—like the soil of a remote island or the foresight of one scientist. These stories show how grasping the mechanisms of our key therapies can reshape entire fields.[1][2]

The Mystery of Rapa Nui

In 1964, the Canadian-led Medical Expedition to Easter Island (METEI) studied the Rapa Nui people's health. Canadian microbiologist Georges Nógrády collected soil samples, suspecting the island's ecosystem held novel microbes with medicinal potential.[3][4]

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